RADiation

RADiation
RAD
200-->20% DEATH
800-->100% DEATH
SENSITIVITY decrease
BM-->GONAD-->INTESTINES

AML

AML=ANLL > 15y
M2 AUER RODS
M4 PAN-Co= EOSINOPHILS/
M5--> GUM

Cancer Incidence

CA INCIDENCE
MALE P LC
FEMALE B LC

DEATH
MALE LP
FEMALE LB

IMMUNO-SUPPRESSANT DRUGS

IMMUNO-SUPPRESSANT DRUGS
C-CAP
C YCLO-SPRN--> T ONLY!
IL2
C YCLO-PHOSHAMIDE
A ZATHIOPRINE=MERCAPTO-PURin-->T&B-DD.CYCLOSPRN
P REDNISONE
~CYCLPH&AZATHIOPRINE

CELL CYCLE

CELL CYCLE:
G0 NSET
G1 ROWTH
S YNTHESIS DNA
G2 ROWTH

MITOSIS:
PRO
MATA
ANA
TELO
VIN-BLASTIN/CRISTIN=CCSpecific
DD.NCCC=ALKYLATING AGENTS
NCCSpecific

Nervous System SUPPORTNG CELLS

NS SUPPORTNG CELLS:
A MOSE wonderful array
A STROCYTE = FRAME
M ICROGLIA = APC
O LIGODENDROGLIA~
S WANN
E PENDYMAL~
ENDOTHELIAL CELL

ALKYLATING CYTOSTATICS: NCCC

N MUSTARD
C YCLOPHOSPHAMIDE
C IS- PLATINE
C lORAMBUCIL

B USULPHAN

ANTI-CA DRUGS

ANTI-CA DRUGS:
BLEOMC- PULM.FIBROS.
METXT- DECREASE B9<-- LEUCOVORIN RESCUE VINCR-->DROPS

DO
XOR-
COR
A NTIBIOTICS+
A LKYLATING=
NO CCSpecific
NCCC-Busulphan

HEMA-TINICS

HEMA-TINICS:
• EPOETIN CRF
• Fe2+ IDA
• B12 IM D.D. B9
• B9 PO- NOT IN
PERNIC. ANEMIA

MEN

MEN 1= 3P:
P ANCREAS~ Z.-EL. /Gastrn
P TH
P ITUITARY
M EN 2
M EDULLARY THYR. CA
PHEOCHROM. +
PTH
M EN 3 SAME 2+
M UCOSAL NEUROMA

ONCOGENES

~
DOMINANT GENES:
c-myc NHL, BURK.
814
N-myc N EROBL.
L-myc L UNG CA
bcl-2 NHL 14, 18
erb-B2 CA
ret MEN
abl- bcr Ph’ 9 22

PHEOCHROMOCYTOMA

1O %
MALIGNANT
2- LATERAL
EXTRA - ADRENAL
Ca2+ -FY
CHILDREN
FAMILIAL  MEN2

CLINIC = 5 P:
P RESSURE B/
P AIN HEADACHE
P ERSPIR.SWEAT
P ALPITATIONS
P ALLOR

ROS HEMATOLOGY: BIG B-BARS

B RUISES - PLT \
I NFECTION
G LANDS / -  LAD

B LOOD LOSS

B ONE PAIN -  LEUKEMIA
A NEMIA
R ASH - LEUKEMIA
S ENS. - PAR-ESTHESIAE
VIT.B12 DEFICIENCY