PARKIN SON

PARKIN SON:
PARKING TREMOR=AT REST
\D2 70% + /Ach

DRUGS=BALSAM:
B ROMO-CRIPTINE
A MANTADINE
L-DOPA
S ELEGILINE
A NTI-M USCARINIC

1. L-DOPA+
CARBI-DOPA-->
PERIPH. INHIBITOR
SE:CHOREA, ON/OFF

2. SELEGILINE
DEPRENYL
MAO-B INHIBITOR DD.MAOI

3. BROMO-CRIPTINE
D-AGONIST~DOPAMINE
ERGOT-->LACTATN STOP

4.ANTI-Ach=M-BLOCKER
BENZ-ATROPINE

5.AMANTADINE-->FLU

ANTI-THYROID DRUGS

ANTI-THYROID DRUGS:
-THION-AMIDE S=C-N
\ORGANIFICTN<--C-MAZL P ER-OXIDASE\ P -S-URACIL\ P ERIPHERAL CONVERSION\ T4-->T3
P MN\ 0.1 %

-KI*30 NORM-->
\VASCUL. before SURGERY
TRANSIENTLY DD.

-131 I*--> PERMANENT
-bAR BLOCK= PROPRANL

MEMBRANE-->PHOSPHO-LIPID

MEMBRANE-->PHOSPHO-LIPID:
GLY----PHOSPH.-->POLAR
CER----FA 2
OL----FA 3 -->

Ph-LIPASE A2 CUT-->C2-->
ARACHIDONIC ACID-->
C OX-->
C YCLIC:
-PGH2 DD.
--> TxA2
-->PGI2
Platelet Gathering Inhibitor=
PROSTACYCLINE
-PGE2-->F2
ABORTION

L IP-OXYGENASE-->
L EUCO-TRIENES
L INEAR 3===double bond
--> ABCDEF 4
CDE 4--> ASTHMA
SRS-A

GABA Cl- CHANNEL

GABA Cl- CHANNEL
OPEN-->IPSP

/DURATion<--BARBI-
DURATes
/FREquency
FREnzodiazepines

Calcium Metabolsim Drug

Ca2 DRUGS:
1. Vit.D--> PO
-ERGO-
-TRIOL-->CRF
2.SAL-CATONIN SC
+ETI-DRONATE
\OSTEO=CLASTS
\BONE RESORPTION
\SERUM Ca2

POSONING

POSONING--> KIDS:
D RUGS C AN C AUSE P OISONING B UT I & L AVAGE C AN C OPE

D RUGS
C AN
C LEANERS
C AUSE
C OSMETICS
P OISONING
P LANTS
I
I PECAC
L AVAGE
C AN
C HARCOAL
C OPE
C ATHARCTICS

DIURETICS

DIURETICS:
1. LOOP--> EDEMA
2. CL-THIAZIDE--> DCT=
Na+ STAYS IN
-BP/, NEPHROGENIC DI
-Ca2 URIA
3. K+ STAys DIURETICS
-S=ALDOSTERONE ANTAGONIST
TA-->Na+ BLOCK
4. C AnH-ASE INHIBITOR-->
PCT= HCO3- STAYS-->
pH DECREASE~ RTA 2
ACID-ZLMD
ACID OSIS
5. OSMOTIC=MANNITOL-->PCT

SEROTONIN ANTA-GONISTS

SEROTONIN ANTA-GONISTS-->
14 RECEPTORS
-MIGRAINE
-CHEMOTH. EMESIS
-CLOZAPINE- ANTI-Schz

IMMUNO-SUPPRESSANT DRUGS

IMMUNO-SUPPRESSANT DRUGS
C-CAP
C YCLO-SPRN--> T ONLY!
IL2
C YCLO-PHOSHAMIDE
A ZATHIOPRINE=MERCAPTO-PURin-->T&B-DD.CYCLOSPRN
P REDNISONE
~CYCLPH&AZATHIOPRINE

CONTRA-CEPTIVES

CONTRA-CEPTIVES:
1.CoC
ESTROGEN-->FSH decrease
PROGESTERN--> LH decrease=
NO OVULATION
L H-->OVU
L ation

2.PoP NON STOP
MUCUS change ONLY-DD. 1

3. MORNING AFTER PILL=
ESTROGEN ONLY
4.IMPLANT NOR-GESTREL~
PROGESTERON--> 5y!

ENDOMETRIAL&OVARIAN CA decrease

GONADAL DRUGS

GONADAL DRUGS:
1. GnRH AGONIST=
LEUPROLIDE
GONADO-RELIN
-PULSE--> /FSH & LH
-CONTINUOUS-->FSH&LH decrease--> PROSTATIC CA

2.CLOMI-PHEN=
REMOVES ESTROGEN
FEED-BACK--> /FSH&LH-->
SO used in IVF

3. DANAZOL-->FSH&LH decrease
-->ENDO-METRIOSIS

4. MENO-TROPIN ~FSH
MENO-PAUSE WOMEN
UR INE
UR oFolin
~CLOMIPHEN USE+
hCG ~ LH

ANTIBIOTICS

ANTIBIOTICS-->
PROTEIN SYNTHESIS
INHIBITORS:
buy AT 30,
CELL at 50
A MINO-GLYCOSIDES
T ETRA-CYCLINES
Cl-AMPHENICOL
E RYTHRO-MYCN
L INCOMYCN
cL indamycin


TETR
A CYCLINE
A CCEPTOR SITE

CHLORAM
P HENICOL
P EPDIDYL SITE

amin
NOglycoside
N EPHROTOXICITY
O TOTOXICITY

ERY-
t ROMYCINE
t RNA -->NO RELEASE

AMPHO-
TERRIBLE SE
TEARS
HOLES IN MEMBRANE

Neuromuscular Blockers

NMJ BLOCK-->
ANESTHESIA
• ND=
C URARE
C OMPETITIVE
• D EPOLARIZING=
SUCC-Ch~ Ach

AchE I USE:
• NMJ BLOCK REVERSAL
• Mgravis
• GLAUCOMA

CHOLESTEROL SYNTHESIS

CHOLESTEROL SYNTHESIS:
Ac.CoA + Ac.CoA=
Ac-ACETYLCoA
4C+
Ac.CoA=
OH-CH3-GLUTARYL-CoA
6C--->
HMG-CoA-RED-ase--->
MEVALONATE=6C--->
/ LONG---> SQUALENE--->
CYCLE---->
LANO-STEROL
4 FUSED RINGS---->

CHOLE-STEROL---->
----> BILE SALTS
--->CS
--->SEX HORMONES
---> Vit. D

ORAL HYPOGLYCEMICS

S-UREA= GLIPIZID
/ S ECRETION b-CELLLS
BI-GUANIDINE
M ETH-FORMINE
M USCLE
/ Glu UPTAKE

ALKYLATING CYTOSTATICS: NCCC

N MUSTARD
C YCLOPHOSPHAMIDE
C IS- PLATINE
C lORAMBUCIL

B USULPHAN

ANTI-CA DRUGS

ANTI-CA DRUGS:
BLEOMC- PULM.FIBROS.
METXT- DECREASE B9<-- LEUCOVORIN RESCUE VINCR-->DROPS

DO
XOR-
COR
A NTIBIOTICS+
A LKYLATING=
NO CCSpecific
NCCC-Busulphan

ATROPIN Side Effects

ATROPIN SE:
RED AS A BEET
MAD- HATTER
HOT- HARE
DRY- BONE
BLOATED-BLADDER

HEMA-TINICS

HEMA-TINICS:
• EPOETIN CRF
• Fe2+ IDA
• B12 IM D.D. B9
• B9 PO- NOT IN
PERNIC. ANEMIA

ANTI- GLAUCOMA DRUGS

ANTI- GLAUCOMA
DRUGS:
1. TIMOL-OL=
b-AR BLOCK
VASO-CONSTROICT.
\ PRODUCTION

1. PILOCARPINE=
M -AGONIST
CILIARY MUSCLE
CONTRACTION+
MYOSIS
D.D. ATROPIN

1. PHYSO-STYGMIN
= AchEI  / Ach~
PILO-CARPINE
2. ACET-AZOLAMID
 \ PRODUCTION~
TIMOLOL

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